The Catalytic Enantioselective Total Synthesis of (+)-Liphagal
This tetracyclic meroterpene has had quite a bit of attention from the synthetic community since its isolation back in 2006 from a Caribbean sponge. Along with other well known natural products such as resveratrol, staurosporine, and wortmannin it's an inhibitor of phosphatidylinositol 3-kinase (PI3K), an enzyme involved in numerous diseases. The fact that those all have wikipedia pages is quite telling. It's also got some cytotoxicity towards various cancer cell lines, but I suspect the reason people keep making it is the unique and interesting 6-7-5-6 ring system.